Hormone Replacement Therapy Associated With Increased Weight Loss When Using GLP1 Medication by Jacob Teitelbaum

Taking tirzepatide for weight loss? Research presented in October, 2025, at The Menopause Society 2025 Annual Meeting in Orlando, Fla., has shown that menopausal women who took tirzepatide had 28 percent more weight loss if they were on hormone replacement therapy (HRT) vs. those menopausal women who were not on HRT. The study looked at 160 women in four groups.

The premenopausal women experienced a significant 18.7 percent loss of total body fat and the perimenopausal women had a significant 18.6 percent loss of total body fat, with 19.9 percent total body fat loss seen in the postmenopausal women taking hormone therapy. The postmenopausal women not taking hormone therapy had significantly less weight loss, i.e., 15.6 percent of total body fat.

Our earlier findings substantiate that hormones can have a significant effect on a subject’s weight. In fibromyalgia and chronic fatigue syndrome, hormones are frequently out of balance, which presents as weight gain.

Weight gain, which increases during menopause, is a major contributor to diabetes, heart disease and other health conditions. Multiple factors promote the American overweight epidemic, including:

• Poor sleep, which is associated with a 30 percent increased risk of obesity.

• A diet high in sugar and refined carbohydrates.

• Sedentary lifestyle.

• Menopause and “Manopause.” In women, estrogen levels drop, metabolism slows and muscle mass decreases, leading to more fat being stored around the abdomen. In men, low testosterone, even if the tests are “normal,” contributes to metabolic syndrome with its associated abdominal weight gain (called a “spare tire), diabetes, hypertension, high cholesterol, as well as heart attacks and stroke.

The health benefits of hormone replacement therapy are now being recognized and addressed. Yet, the critical distinction between synthetic versus bioidentical hormones is still being overlooked. HRT with bioidentical hormones has a much better safety record and is the preferred approach.

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